RESUMO
In cats, the calcium antagonist Verapamil depressed vein constrictor responses to noradrenaline and angiotensine II both under conditions of wholesome endothelium and physical-chemical and chemical de-endothelisation. Following the de-endothelisation the vein responses recovered. The data obtained suggest that this recovery seems to be due to opening of new calcium channels that are independent of the Verapamil effect.
Assuntos
Bloqueadores dos Canais de Cálcio/farmacologia , Endotélio Vascular/fisiologia , Resistência Vascular/efeitos dos fármacos , Vasoconstrição/efeitos dos fármacos , Veias/fisiologia , Verapamil/farmacologia , Angiotensina II/farmacologia , Animais , Cálcio/antagonistas & inibidores , Gatos , Norepinefrina/farmacologia , Resistência Vascular/fisiologia , Vasoconstritores/farmacologiaRESUMO
In cats anesthetized with Uretan and perfused with a constant blood volume, Taurine induced responses of neither arterial nor venous vessels of the skeletal muscle but increased the capillary filtration coefficient without any significant change of the capillary pressure in the skeletal muscle's microvessels. Taurine also increased both the constrictor and the dilatory responses of the arterial and venous vessels. The mechanism of the Taurine effects upon the smooth muscle elements of arteries and veins as well as upon proper mechanisms of capillary pressure control and capillary filtration coefficient, seems to be calcium-dependent.
Assuntos
Agonistas alfa-Adrenérgicos/farmacologia , Agonistas Adrenérgicos beta/farmacologia , Isoproterenol/farmacologia , Músculo Esquelético/irrigação sanguínea , Músculo Liso Vascular/efeitos dos fármacos , Norepinefrina/farmacologia , Taurina/farmacologia , Animais , Artérias , Cálcio/metabolismo , Permeabilidade Capilar , Gatos , Microcirculação , Contração Muscular , Relaxamento Muscular , Músculo Liso Vascular/fisiologia , Capacitância Vascular/efeitos dos fármacos , Resistência Vascular/efeitos dos fármacos , VeiasRESUMO
In perfusion of the cat hemodynamically isolated kidney with a constant blood flow volume, responses of venous vessels to noradrenaline did not depend on the venous outflow pressure level and only involved a diminishing of the blood filling which distinguishes kidneys from other organs. The renal veins' capacity decreased in response to noradrenaline practically completely disappears in high values of the venous outflow pressure. The renal capillary filtration coefficient was shown to equal 0.21 +/- 0.11, whereas the effect of changes in renal vein's pressure on implementation of the microvessels' exchange function in determined by the shifts of capillary hydrostatic pressure.
Assuntos
Permeabilidade Capilar , Rim/irrigação sanguínea , Capacitância Vascular , Animais , Gatos , Feminino , Masculino , Microcirculação , Norepinefrina/farmacologia , Artéria Renal/fisiologia , Veias Renais , Resistência Vascular , Vasoconstritores/farmacologia , Pressão VenosaRESUMO
Verapamyl administered to the intestine circulation in the dose evoking no shifts in the arterial and venous resistance or in the vascular capacity, decreased 2- or 3-fold both the constrictor and dilatory responses of the arterial vessels. Against the background of Verapamyl, noradrenaline and isoproterenol did not practically change either capacity or resistance in the veins. Responses of veins to angiotensin II increased 10-fold and more, whereas they were absent after administration of atropine into the intestine circulation. Constrictor and dilatory responses of veins need to a greater extent than the arteries penetration of external calcium ions to their myocytes.
Assuntos
Cálcio/metabolismo , Intestino Delgado/fisiologia , Músculo Liso Vascular/fisiologia , Vasoconstrição/fisiologia , Vasodilatação/fisiologia , Animais , Artérias/fisiologia , Gatos , Feminino , Intestino Delgado/irrigação sanguínea , Masculino , Músculo Liso Vascular/citologia , Capacitância Vascular/fisiologia , Veias/fisiologiaAssuntos
Músculo Esquelético/irrigação sanguínea , Resistência Vascular/fisiologia , Veias/fisiologia , Animais , Bloqueadores dos Canais de Cálcio/farmacologia , Gatos , Endotélio Vascular/fisiologia , Membro Posterior , Contração Muscular/efeitos dos fármacos , Contração Muscular/fisiologia , Músculo Esquelético/inervação , Norepinefrina/farmacologia , Resistência Vascular/efeitos dos fármacos , Vasoconstritores/farmacologia , Vasodilatadores/farmacologia , Veias/efeitos dos fármacos , Pressão Venosa/efeitos dos fármacos , Pressão Venosa/fisiologia , Verapamil/farmacologiaAssuntos
Bulbo/fisiologia , Músculo Esquelético/irrigação sanguínea , Capacitância Vascular/fisiologia , Resistência Vascular/fisiologia , Veias/fisiologia , Animais , Artérias/fisiologia , Gatos , Estimulação Elétrica , Contração Muscular/fisiologia , Relaxamento Muscular/fisiologia , Músculo Esquelético/fisiologia , Músculo Liso Vascular/fisiologiaAssuntos
Ar , Banhos/métodos , Dióxido de Carbono/uso terapêutico , Isquemia Miocárdica/reabilitação , Radônio/uso terapêutico , Adulto , Idoso , Angina Pectoris/fisiopatologia , Angina Pectoris/reabilitação , Terapia Combinada , Hemodinâmica , Humanos , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/fisiopatologia , Esforço FísicoRESUMO
Under conditions of perfusion of the small intestine's vessels with constant volume of the auto-blood, stationary shifts of the arterial perfusion pressure by +/- 50 mm Hg and/or blood flow by +/- 50% of the initial level practically did not affect the size of the exchange surface of the organ's microvessel bed (the capillary filtration coefficient) or the average capillary pressure in artificially stabilised pressure of venous outflow at the level of 6 mm Hg. However, under conditions of normo-, hypo- and hypertone of the small vessels' smooth muscles, the shifts of the venous outflow pressure (from 0 to 24 mm Hg) increased the exchange surface of the microvessels and the average capillary pressure. The mechanisms of the shifts in microhemodynamics and transcapillary exchange of fluid are discussed.
Assuntos
Pressão Sanguínea/fisiologia , Absorção Intestinal/fisiologia , Intestino Delgado/irrigação sanguínea , Animais , Capilares/fisiologia , Gatos , Feminino , Pressão Hidrostática , Intestino Delgado/fisiologia , Masculino , Músculo Liso Vascular/fisiologia , Perfusão/métodos , Pressão Venosa/fisiologiaRESUMO
Preliminary artificial venous hypertension of hindlimbs for 4-6 weeks was followed by comparison of resistive, capacitance and metabolic functions of the m. gastrocnemius' vessels performed in experimental and control cats with different levels of initial pressure of venous outflow. An increase of precapillary resistance, of the capillary filtration coefficient, a decrease of distensibility of the muscle venous bed, and constancy of postcapillary resistance and mean capillary pressure, were found in experimental animals. Mechanogenic responses of the muscle venous vessels to a rapid increase of the pressure in them were augmented in animals with chronic venous hypertension. The mechanisms of the effect of prolonged venous hypertension on functions of skeletal muscle's vessels, are discussed.
Assuntos
Músculos/irrigação sanguínea , Pressão Venosa/fisiologia , Animais , Gatos , Feminino , Hemodinâmica/fisiologia , Membro Posterior/irrigação sanguínea , Ligadura , Masculino , Músculos/fisiologia , Fatores de Tempo , Resistência Vascular/fisiologia , Veia Cava InferiorRESUMO
Modelled venous insufficiency of the hind limbs of cats (ligation of the posterior vena cava for 4-6 weeks) led to structural reorganization of the venous walls of the gastrocnemius muscle, which was manifested by a sharp increase of stretchability of the venous bed of the muscle if the activity of the smooth muscles was removed by papaverine, and by significant loss of the sensitivity of the smooth muscles of the intramuscular veins to noradrenaline as regards function. The range of adrenergic changes of postcapillary resistance and capillary pressure was reduced sharply in animals with venous insufficiency. This may be among the causes of disorders of metabolic processes in the skeletal muscles in venous insufficiency.
Assuntos
Músculos/irrigação sanguínea , Insuficiência Venosa/fisiopatologia , Animais , Capilares/fisiopatologia , Gatos , Veias/fisiopatologiaRESUMO
In regimen of the constant blood flow perfusion of shank and small intestine of cat combined effect of hypoxia (10% O2 in N2) and hypothermia (about 30 degrees C) involved a decrease in precapillary resistance, an increase in capillary filtration coefficient in both vascular regions, an increase in postcapillary resistance and in mean capillary pressure in the intestine, and their decrease in the shank. In hypothermia, the hypoxic stimulus induced insignificant shifts in all the parameters under study in both organs. Dependence of hypoxic changes of macro- and microhemodynamics on the activity of adrenergic receptors in the cooled organism was studied on decentralized shank of cat. After cooling of cat and blockade of alpha-adrenoreceptors hypoxic hypoxia caused much greater reduction of precapillary resistance of shank, more striking (by 3 times) increase of capillary filtration coefficient and the increase of capillary pressure and postcapillary resistance in contrast with their decrease to hypoxia under hypothermia before alpha-blockade. Beta-adrenoreceptor blockade had no influence on the changes of the resistance and exchange function of skeletal muscle (shank) blood vessels evoked by hypoxia under cooling. Systemic arterial pressure are diminished during hypoxia under the normothermic conditions of animals. Such kind shifts caused especially by the decreasing of the total peripheral resistance; cardiac output are small raised in this situation. But combined influence of hypoxia and hypothermia evoked the pressor shifts of the systemic arterial pressure because of less decrease of total peripheral resistance and more remarkable rise of cardiac output. Hypoxic stimulus caused both in normothermia and hypothermia conditions caused the rising of venous return.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Circulação Sanguínea/fisiologia , Hemodinâmica/fisiologia , Hipotermia/fisiopatologia , Hipóxia/fisiopatologia , Animais , Resistência Capilar/fisiologia , Gatos , Músculo Liso/fisiopatologia , Músculo Liso Vascular/fisiopatologia , Temperatura , Fatores de TempoAssuntos
Músculos/irrigação sanguínea , Vasoconstrição/fisiologia , Angiotensina II/farmacologia , Animais , Artérias/efeitos dos fármacos , Artérias/fisiologia , Gatos , Relação Dose-Resposta a Droga , Feminino , Masculino , Músculos/efeitos dos fármacos , Norepinefrina/farmacologia , Compostos Orgânicos , Resistência Vascular/efeitos dos fármacos , Resistência Vascular/fisiologia , Vasoconstrição/efeitos dos fármacos , Vasoconstritores/farmacologia , Vasodilatadores/farmacologia , Veias/efeitos dos fármacos , Veias/fisiologiaRESUMO
Two pairs of stimuli: isoproterenol and histamine, and isoproterenol and papaverine, did not enhance the effect of their separate components on either arterial or venous vessels, the dilatory responses not exceeding the vascular responses to separate agents. However, if the vascular responses to an isolated component of the pairs differed, then the effect of a pair of stimuli was equal to a greater response from the responses to an isolated component. Venous vessels differed from arterial ones in that their response to a combined action of above substances was sharply reduced as compared to responses to isoproterenol.